- GrantDate:
- 14/05/2009
- Title:
- SINGLE POT PROCESS FOR THE PREPATATION OF ARTEETHER FROM ARTEMISININ
- Abstract:
- The present invention provides a method for the preparation of arteether from artemisinin in one pot in just about 4 hours comprising reduction of artemisinin into dihydroartemisinin by less quantity of sodium borohydride in ethanol at room temperature in the presence of a novel polyhydroxy catalyst, acylation of dihydroartemisinin in the presence of an acid catalyst, extraction of arteether from an aqueous reaction mixture using 1% ethyl acetate in n-hexane followed by workup and purification of the impure arteether to yield 80-86% (w/w) pure alpha, beta arteether.
- InventorName:
- RAJENDRA SINGH BHAKUNI,AMIT TEWARI,TARUN SINGH,SUMAN PREET SINGH KHANUJA
- CountryGranted:
- INDIA
