 233817 |
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- GrantDate:
- 09/04/2009
- Title:
- AN IMPROVED PROCESS FOR THE ISOLATION OF ANDROGRAPHOLIDES FROM ANDROGRAPHIS PANICULATA
- Abstract:
- The present invention provides an improved process for the isolation of andrographolide from Andrographis paniculata plant. The steps are: extracting the powdered plant parts with polar solvent, partitioned with a non polar solvent, evaporating the non polar solvent, dissolving a residue in the solvent and crystallization, filtering the crystal of andrographolide and employing chromatography of filtrate after concentration to obtain remaining andrographolide and other compounds. The bulkness of non polar solvent extract reduced (35-40%) due to partitioning step, which improved the crystallization of andrographolide up 80%. This process improved the yield of andrographolide by 10-15% and decrease the cost of production due to reuse of solvent used in partition as well as extraction and reduced the quantity of silica gel needed for separation of remaining andrographolide through chromatography.
- InventorName:
- DHARAM CHAND JAIN, SHIWANI SINGH, BALI RAM TYAGI, SUDEEP TANDON
- CountryGranted:
