 234334 |
|---|
|
|
- GrantDate:
- 25/05/2009
- Title:
- AN IMPROVED PROCESS FOR THE PREPARATION OF ARTETHERS FROM DIHYDROARTEMISININ
- Abstract:
- This invention relates to a process for the preparation of artether derivatives of dihydroartemisinin. The dihydroartemisinin is derived from artemisinin, which is a unique sesquiterpene lactone endoperoxide isolated from the plant Artemisia annua L. Artethers prepared for the process of the invention is useful for the treatment of uncomplicated/severe complicated/cerebral and MDR malaria caused mainly by Plasmodius falciparum. The process steps are:dissolving dihydroartemisinin in a mixture of non polar solvent and alcohols in a ratio in the range of 5:1-10:1 under stirring at a temperature in the range of 50-60°C, adding an acid catalyst such as anhydrous aluminum chloride (AICI3) to the reaction mixture and maintaining for a period of 3-4 hours, neutralizing by known method, washing and drying over conventional anhydrous inorganic salts recovering artethers by conventional methods.
- InventorName:
- ASISH KUMAR BHATTACHARYA,SUMAN PREET SINGH KHANUJA,DHARAM CHAND JAIN
- CountryGranted:
- NA
